Other Diseases
“Mitochondrial dysfunctions, including lowered levels of ATP, decreased phosphocreatine synthesis and impaired oxidative phosphorylation, are heavily involved in the pathophysiology of both MS and ME/CFS. The findings produced by neuroimaging techniques are quite similar in both illnesses and show decreased cerebral blood flow, atrophy, gray matter reduction, white matter hyperintensities, increased cerebral lactate and choline signaling and lowered acetyl-aspartate levels.”
Quick Summary
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Extended List of Studies (by year)
2015-2017
Hope, disappointment and perseverance: Reflections of people with Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis participating in biomedical research. A qualitative focus group study. [PDF]
Lacerda EM, McDermott C, Kingdon CC, Butterworth J, Cliff JM, Nacul L. Health Expect. 2018
Multiple sclerosis (MS) was chosen as a comparison disease for ME/CFS, because while MS patients also experience chronic fatigue and disabling symptoms, the aetiology of MS is comparatively well understood with definitive diagnostic tests. People with MS have a broadly similar experience of disability, restricted lifestyle and stress contingent to the illness, but without the specific challenges presented by lack of a diagnostic test or social stigma. For this study, we explored the ideas of the UKMEB participants with MS and ME/CFS on our preliminary biomedical research findings and their dissemination, and on future biomedical research priorities.
Physiological measures in participants with chronic fatigue syndrome, multiple sclerosis and healthy controls following repeated exercise: a pilot study.
Hodges LD, et al. Clin Physiol Funct Imaging. 2017
[HIGHLIGHT] A Preliminary Comparative Assessment of the Role of CD8+ T Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis. [PDF]
Brenu EW, Broadley S, Nguyen T, Johnston S, Ramos S, Staines D, Marshall-Gradisnik S. J Immunol Res. 2016
The results suggest significant deficits in the expression of receptors and adhesion molecules on subsets of CD8+ T cells in both MS and CFS/ME patients. These deficits reported may contribute to the pathogenesis of these diseases
Pilot Study of Natural Killer Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis.
Huth TK, et al. Scand J Immunol. 2016
Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is associated with pandemic influenza infection, but not with an adjuvanted pandemic influenza vaccine. [Full Text]
Magnus P, Gunnes N, Tveito K, Bakken IJ, Ghaderi S, Stoltenberg C, Hornig M, Lipkin WI, Trogstad L, Håberg SE. Vaccine. 2015
Pandemic influenza A (H1N1) infection was associated with a more than two-fold increased risk of CFS/ME.
2010-2014
[HIGHLIGHT] Multiple Sclerosis/Chronic Fatigue Syndrome overlap: When two common disorders collide. [Full Text]
Gaber TA, Oo WW, Ringrose H. NeuroRehabilitation. 2014
MS and CFS/ME are two common conditions with increased prevalence in middle aged females. The study results suggest that the two conditions may co-exist.
(Psychology) A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior. [PDF]
Morris G, Anderson G, Galecki P, Berk M, Maes M. BMC Med. 2013
Differences and similarities between sickness behavior (an adaptive response induced by proinflammatory cytokines) and ME/CFS are discussed. The article concludes that these are two different conditions.
[HIGHLIGHT] Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics. [PDF]
Morris G, et al. BMC Med. 2013
‘Encephalomyelitis disseminata' (multiple sclerosis) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are both classified as diseases of the central nervous system by the World Health Organization. This review aims to compare the phenomenological and neuroimmune characteristics of MS with those of ME/CFS.
Mitochondrial dysfunctions, including lowered levels of ATP, decreased phosphocreatine synthesis and impaired oxidative phosphorylation, are heavily involved in the pathophysiology of both MS and ME/CFS. The findings produced by neuroimaging techniques are quite similar in both illnesses and show decreased cerebral blood flow, atrophy, gray matter reduction, white matter hyperintensities, increased cerebral lactate and choline signaling and lowered acetyl-aspartate levels.
[HIGHLIGHT] Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls. [PDF]
White AT, et al. Psychosom Med. 2012
Patients with CFS had greater postexercise increases in fatigue and pain (10-29 points above baseline, p < .001) and greater mRNA increases in purinergic type 2X4 receptor, transient receptor potential vanilloid type 1, CD14, and all adrenergic receptors than controls (mean ± standard error = 1.3 ± 0.14- to 3.4 ± 0.90-fold increase above baseline, p = .04-.005).
Postexercise mRNA increases in metabolite-detecting receptors were unique to patients with CFS, whereas both patients with MS and patients with CFS showed abnormal increases in adrenergic receptors.
2005-2009
The experience of cancer-related fatigue and chronic fatigue syndrome: a qualitative and comparative study. [Full Text]
*Bennett B, Goldstein D, Friedlander M, Hickie I, Lloyd A. J Pain Symptom Manage. 2007
Qualitatively, cancer related fatigue appears closely related to CFS.
[HIGHLIGHT] Generalized joint hypermobility is more common in chronic fatigue syndrome than in healthy control subjects.
Nijs J, et al. J Manipulative Physiol Ther. 2006
Compared with the healthy volunteers (4.3%, 3/68), significantly more patients with CFS (20.6%, 14/69) fulfilled the criteria for generalized joint hypermobility (Fisher exact test, P < .004).